2021 — present · 21 modifications
| Modification | Power | 0–100 km/h | Drive | Gearbox |
|---|---|---|---|---|
| S350d 2.9 | 286 hp | 6.4 s | tdr-rear | trans-automatic |
| S350d 2.9 | 286 hp | 6.4 s | tdr-rear | trans-automatic |
| S350d 2.9 | 313 hp | 5.5 s | tdr-rear | trans-automatic |
| S350d 2.9 | 313 hp | 5.5 s | tdr-4x4 | trans-automatic |
| S350d 2.9 4Matic | 286 hp | 6.2 s | tdr-4x4 | trans-automatic |
| S350d 2.9 4Matic | 286 hp | 6.2 s | tdr-4x4 | trans-automatic |
| S400d 2.9 4Matic | 330 hp | 5.4 s | tdr-4x4 | trans-automatic |
| S400d 2.9 4Matic | 330 hp | 5.4 s | tdr-4x4 | trans-automatic |
| S450 3.0 4Matic | 367 hp | 5.1 s | tdr-4x4 | trans-automatic |
| S450d 3.0 4Matic | 367 hp | 5 s | tdr-4x4 | trans-automatic |
| S450e 3.0 | 408 hp | 5.9 s | tdr-rear | trans-automatic |
| S500 3.0 4Matic | 435 hp | 4.9 s | tdr-4x4 | trans-automatic |
| S500 3.0 4Matic | 435 hp | 4.9 s | tdr-4x4 | trans-automatic |
| S500 4Matic | 449 hp | 4.7 s | tdr-4x4 | trans-automatic |
| S580 4.0 4Matic | 503 hp | 4.4 s | tdr-4x4 | trans-automatic |
| S580 4.0 4Matic | 503 hp | 4.4 s | tdr-4x4 | trans-automatic |
| S580 4.0 4Matic | 496 hp | 4.4 s | tdr-4x4 | trans-automatic |
| S580e 3.0 | 510 hp | 5.2 s | tdr-rear | trans-automatic |
| S580e 3.0 | 510 hp | 5.2 s | tdr-rear | trans-automatic |
| S580e 3.0 4Matic | 510 hp | 4.9 s | tdr-4x4 | trans-automatic |
| S580e 3.0 4Matic | 510 hp | 4.9 s | tdr-4x4 | trans-automatic |