2017 — 2021 · 21 modifications
| Modification | Power | 0–100 km/h | Drive | Gearbox |
|---|---|---|---|---|
| S350d 2.9 AT | 249 hp | 5.8 s | tdr-4x4 | trans-automatic |
| S350d 2.9 AT | 286 hp | 5.8 s | tdr-4x4 | trans-automatic |
| S350d 2.9 AT | 286 hp | 6 s | tdr-rear | trans-automatic |
| S350d 2.9 AT | 286 hp | 5.8 s | tdr-4x4 | trans-automatic |
| S400d 2.9 AT | 340 hp | 5.2 s | tdr-4x4 | trans-automatic |
| S400d 2.9 AT | 340 hp | 5.4 s | tdr-rear | trans-automatic |
| S400d 2.9 AT | 340 hp | 5.2 s | tdr-4x4 | trans-automatic |
| S450 3.0 AT | 367 hp | 4.9 s | tdr-4x4 | trans-automatic |
| S450 3.0 AT | 367 hp | — | tdr-rear | trans-automatic |
| S450 3.0 AT | 367 hp | 5.5 s | tdr-4x4 | trans-automatic |
| S500 3.0 AT | 435 hp | 4.8 s | tdr-rear | trans-automatic |
| S500e 3.0 AT | 442 hp | 5.2 s | tdr-rear | trans-automatic |
| S560 4.0 AT | 469 hp | 4.6 s | tdr-4x4 | trans-automatic |
| S560 4.0 AT | 469 hp | 4.7 s | tdr-rear | trans-automatic |
| S560 4.0 AT | 469 hp | 4.6 s | tdr-rear | trans-automatic |
| S560 4.0 AT | 469 hp | 4.6 s | tdr-4x4 | trans-automatic |
| S560 4.0 AT | 469 hp | 4.6 s | tdr-4x4 | trans-automatic |
| S560 4.0 AT | 469 hp | 4.6 s | tdr-rear | trans-automatic |
| S560e 3.0 AT | 367 hp | 5 s | tdr-rear | trans-automatic |
| S560e 3.0 AT | 367 hp | 5 s | tdr-rear | trans-automatic |
| S600 6.0 AT | 530 hp | 4.6 s | tdr-rear | trans-automatic |