2005 — 2009 · 21 modifications
| Modification | Power | 0–100 km/h | Drive | Gearbox |
|---|---|---|---|---|
| S300 3.0 AT | 235 hp | 8.2 s | tdr-rear | trans-automatic |
| S320d 3.0 AT | 235 hp | 7.5 s | tdr-rear | trans-automatic |
| S320d 3.0 AT | 235 hp | 7.5 s | tdr-4x4 | trans-automatic |
| S320d 3.0 AT | 235 hp | 7.5 s | tdr-4x4 | trans-automatic |
| S320d 3.0 AT | 235 hp | 7.5 s | tdr-rear | trans-automatic |
| S350 3.5 AT | 272 hp | 7.2 s | tdr-4x4 | trans-automatic |
| S350 3.5 AT | 272 hp | 7.2 s | tdr-rear | trans-automatic |
| S350 3.5 AT | 272 hp | 7.3 s | tdr-rear | trans-automatic |
| S350 3.5 AT | 272 hp | 7.2 s | tdr-4x4 | trans-automatic |
| S420d 4.0 AT | 320 hp | 6 s | tdr-rear | trans-automatic |
| S420d 4.0 AT | 320 hp | 6 s | tdr-rear | trans-automatic |
| S450 4.7 AT | 340 hp | 5.9 s | tdr-4x4 | trans-automatic |
| S450 4.7 AT | 340 hp | 5.9 s | tdr-rear | trans-automatic |
| S450 4.7 AT | 340 hp | 5.9 s | tdr-4x4 | trans-automatic |
| S450 4.7 AT | 340 hp | 5.9 s | tdr-rear | trans-automatic |
| S500 5.5 AT | 388 hp | 5.4 s | tdr-4x4 | trans-automatic |
| S500 5.5 AT | 388 hp | 5.4 s | tdr-rear | trans-automatic |
| S500 5.5 AT | 388 hp | 5.6 s | tdr-rear | trans-automatic |
| S500 5.5 AT | 388 hp | 5.4 s | tdr-4x4 | trans-automatic |
| S600 5.5 AT | 517 hp | 4.6 s | tdr-rear | trans-automatic |
| S600 6.2 AT | 525 hp | 4.6 s | tdr-rear | trans-automatic |