2005 — 2008 · 8 modifications
| Modification | Power | 0–100 km/h | Drive | Gearbox |
|---|---|---|---|---|
| ML280CDI 3.0 AT | 190 hp | 9.8 s | tdr-4x4 | trans-automatic |
| ML320CDI 3.0 AT | 218 hp | 8.6 s | tdr-4x4 | trans-automatic |
| ML320CDI 4.0 AT | 224 hp | 8.6 s | tdr-4x4 | trans-automatic |
| ML350 3.5 AT | 272 hp | 8.4 s | tdr-4x4 | trans-automatic |
| ML350CDI 4.0 AT | 211 hp | 8.7 s | tdr-4x4 | trans-automatic |
| ML420CDI 4.0 AT | 306 hp | 6.5 s | tdr-4x4 | trans-automatic |
| ML500 5.0 AT | 306 hp | 6.9 s | tdr-4x4 | trans-automatic |
| ML550 5.5 AT | 388 hp | 5.8 s | tdr-4x4 | trans-automatic |