2008 — 2011 · 7 modifications
| Modification | Power | 0–100 km/h | Drive | Gearbox |
|---|---|---|---|---|
| ML300CDI 3.0 AT | 190 hp | 9.8 s | tdr-4x4 | trans-automatic |
| ML300CDI 3.0 AT | 204 hp | 8.2 s | tdr-4x4 | trans-automatic |
| ML320CDI 3.0 AT | 224 hp | 8.6 s | tdr-4x4 | trans-automatic |
| ML350 3.5 AT | 272 hp | 8.4 s | tdr-4x4 | trans-automatic |
| ML350CDI 3.0 AT | 231 hp | 7.6 s | tdr-4x4 | trans-automatic |
| ML420CDI 4.0 AT | 306 hp | 6.5 s | tdr-4x4 | trans-automatic |
| ML500 5.5 AT | 388 hp | 5.8 s | tdr-4x4 | trans-automatic |