2017 — 2022 · 8 modifications
| Modification | Power | 0–100 km/h | Drive | Gearbox |
|---|---|---|---|---|
| CLS220d 2.0 | 194 hp | 7.5 s | tdr-rear | trans-automatic |
| CLS300d 2.0 AT 4Matic | 245 hp | 6.4 s | tdr-4x4 | trans-automatic |
| CLS350 AT 2.0 | 299 hp | 5.9 s | tdr-rear | trans-automatic |
| CLS350 AT 2.0 4Matic | 299 hp | 6.2 s | tdr-4x4 | trans-automatic |
| CLS350d 2.9 AT 4Matic | 249 hp | 5.7 s | tdr-4x4 | trans-automatic |
| CLS350d 2.9 AT 4Matic | 286 hp | 5.7 s | tdr-4x4 | trans-automatic |
| CLS400d 2.9 AT 4Matic | 340 hp | 5 s | tdr-4x4 | trans-automatic |
| CLS450 3.0 4Matic | 367 hp | 4.8 s | tdr-4x4 | trans-automatic |