2021 — present · 5 modifications
| Modification | Power | 0–100 km/h | Drive | Gearbox |
|---|---|---|---|---|
| CLS220d 2.0 | 194 hp | 7.5 s | tdr-rear | trans-automatic |
| CLS300d 2.0 4Matic | 265 hp | 6.4 s | tdr-4x4 | trans-automatic |
| CLS350 AT 2.0 | 299 hp | 6.1 s | tdr-rear | trans-automatic |
| CLS400d 2.9 4Matic | 330 hp | 5.2 s | tdr-4x4 | trans-automatic |
| CLS450 3.0 4Matic | 367 hp | 4.8 s | tdr-4x4 | trans-automatic |