2010 — 2014 · 17 modifications
| Modification | Power | 0–100 km/h | Drive | Gearbox |
|---|---|---|---|---|
| CLS250CDI 2.1 AT | 204 hp | 7.8 s | tdr-rear | trans-automatic |
| CLS250CDI 2.1 AT | 204 hp | 7.5 s | tdr-rear | trans-automatic |
| CLS250CDI 2.1 MT | 204 hp | 10.5 s | tdr-rear | trans-manual |
| CLS350 3.5 AT | 306 hp | 6.7 s | tdr-rear | trans-automatic |
| CLS350 3.5 AT | 306 hp | 6.1 s | tdr-rear | trans-automatic |
| CLS350BlueTEC 3.0 AT | 252 hp | 6.7 s | tdr-4x4 | trans-automatic |
| CLS350BlueTEC 3.0 AT | 252 hp | 6.6 s | tdr-rear | trans-automatic |
| CLS350CDI 3.0 AT | 265 hp | 6.7 s | tdr-4x4 | trans-automatic |
| CLS350CDI 3.0 AT | 265 hp | 6.6 s | tdr-rear | trans-automatic |
| CLS350CDI 3.0 AT | 265 hp | 6.4 s | tdr-4x4 | trans-automatic |
| CLS350CDI 3.0 AT | 265 hp | 6.2 s | tdr-rear | trans-automatic |
| CLS500 4.7 AT | 408 hp | 5.3 s | tdr-4x4 | trans-automatic |
| CLS500 4.7 AT | 408 hp | 5 s | tdr-rear | trans-automatic |
| CLS500 4.7 AT | 408 hp | 5.2 s | tdr-4x4 | trans-automatic |
| CLS500 4.7 AT | 402 hp | 5.1 s | tdr-rear | trans-automatic |
| CLS500 4.7 AT | 402 hp | 5.1 s | tdr-4x4 | trans-automatic |
| CLS500 4.7 AT | 408 hp | 5.2 s | tdr-rear | trans-automatic |