2014 — 2018 · 26 modifications
| Modification | Power | 0–100 km/h | Drive | Gearbox |
|---|---|---|---|---|
| CLS220BlueTEC 2.1 AT | 170 hp | 8.6 s | tdr-rear | trans-automatic |
| CLS250CDI 2.1 AT | 204 hp | 7.9 s | tdr-4x4 | trans-automatic |
| CLS250CDI 2.1 AT | 204 hp | 7.5 s | tdr-rear | trans-automatic |
| CLS250CDI 2.1 AT | 204 hp | 8.1 s | tdr-4x4 | trans-automatic |
| CLS250CDI 2.1 AT | 204 hp | 7.7 s | tdr-rear | trans-automatic |
| CLS350BlueTEC 2.1 AT | 170 hp | 8.3 s | tdr-rear | trans-automatic |
| CLS350BlueTEC 3.0 AT | 249 hp | 6.7 s | tdr-4x4 | trans-automatic |
| CLS350BlueTEC 3.0 AT | 258 hp | 6.5 s | tdr-rear | trans-automatic |
| CLS350BlueTEC 3.0 AT | 258 hp | 6.7 s | tdr-4x4 | trans-automatic |
| CLS350BlueTEC 3.0 AT | 249 hp | 6.8 s | tdr-4x4 | trans-automatic |
| CLS350BlueTEC 3.0 AT | 258 hp | 6.6 s | tdr-rear | trans-automatic |
| CLS350BlueTEC 3.0 AT | 258 hp | 6.8 s | tdr-4x4 | trans-automatic |
| CLS400 3.0 AT | 333 hp | 5.3 s | tdr-4x4 | trans-automatic |
| CLS400 3.0 AT | 333 hp | 5.3 s | tdr-rear | trans-automatic |
| CLS400 3.0 AT | 333 hp | 5.4 s | tdr-4x4 | trans-automatic |
| CLS400 3.0 AT | 333 hp | 5.4 s | tdr-rear | trans-automatic |
| CLS400 3.5 AT | 333 hp | 5.3 s | tdr-rear | trans-automatic |
| CLS400 3.5 AT | 333 hp | 5.3 s | tdr-4x4 | trans-automatic |
| CLS400 3.5 AT | 333 hp | 5.4 s | tdr-4x4 | trans-automatic |
| CLS400 3.5 AT | 333 hp | 5.4 s | tdr-rear | trans-automatic |
| CLS500 4.7 AT | 402 hp | 5.1 s | tdr-rear | trans-automatic |
| CLS500 4.7 AT | 402 hp | 5.1 s | tdr-4x4 | trans-automatic |
| CLS500 4.7 AT | 408 hp | 4.8 s | tdr-rear | trans-automatic |
| CLS500 4.7 AT | 408 hp | 4.8 s | tdr-4x4 | trans-automatic |
| CLS500 4.7 AT | 408 hp | 4.9 s | tdr-4x4 | trans-automatic |
| CLS500 4.7 AT | 408 hp | 4.9 s | tdr-rear | trans-automatic |