2004 — 2008 · 5 modifications
| Modification | Power | 0–100 km/h | Drive | Gearbox |
|---|---|---|---|---|
| CLS320CDI 3.0 AT | 224 hp | 7 s | tdr-rear | trans-automatic |
| CLS350 3.5 AT | 272 hp | 6.7 s | tdr-rear | trans-automatic |
| CLS350CGI 3.5 AT | 292 hp | 6.7 s | tdr-rear | trans-automatic |
| CLS500 5.0 AT | 306 hp | 6.1 s | tdr-rear | trans-automatic |
| CLS500 5.5 AT | 388 hp | 5.4 s | tdr-rear | trans-automatic |