2008 — 2011 · 6 modifications
| Modification | Power | 0–100 km/h | Drive | Gearbox |
|---|---|---|---|---|
| CLS300 3.0 AT | 231 hp | 7.7 s | tdr-rear | trans-automatic |
| CLS350 3.5 AT | 272 hp | 7 s | tdr-rear | trans-automatic |
| CLS350CDI 3.0 AT | 224 hp | 7 s | tdr-rear | trans-automatic |
| CLS350CDI 3.0 AT | 265 hp | 6.2 s | tdr-rear | trans-automatic |
| CLS350CGI 3.5 AT | 292 hp | 6.7 s | tdr-rear | trans-automatic |
| CLS500 5.5 AT | 388 hp | 5.4 s | tdr-rear | trans-automatic |